Objective: Tuberculosis is a bacterial disease caused by a single infectious agent, resulting in significant mortality and morbidity worldwide. Almost a quarter of the world’s population is infected with tuberculosis bacillus, and about two million people die each year from this disease. In this study, it was aimed to genotyping Mycobacterium tuberculosis compleks (MT) isolates in our province and to obtain molecular epidemiological data of these isolates.

Methods: In the study, genotyping of 103 MTC isolates in the Mersin University Faculty of Medicine Department of Medical Microbiology Mycobacteriology Laboratory was performed using spoligotyping and MIRU-VNTR methods.

Results: As a result of molecular genotyping, it was observed that 103 isolates were distributed in 10 spoligotyping clusters. It was determined that the T family constituted the largest cluster with 48 (46.6%) isolates. This was followed by 16 (15.5%) isolates of the Haarlem family, 13 (12.6%) isolates of the TUR family, 10 (9.7%) isolates of the S family, four (3.9%) isolates of the Beijing and LAM families, three (2.9%) isolates of the Bovis and NEW-1 families were followed by Delhi/CAS and H37Rv families, with one (0.9%) isolate.

Conclusion: As a result of the study, it was determined that the most common family was the T family with a rate of 46.6%. The Beijing family, which was reported to be associated with multi-drug resistant tuberculosis in previous studies, has now been identified in our region. It is thought that the combination of MIRU-VNTR and spoligotyping methods will be useful in the control and elimination of tuberculosis in the population in that region by monitoring the motility of M. tuberculosis in the region where molecular epidemiological studies are carried out.