Objective: Human papillomavirus (HPV) is a small, double-stranded DNA virus that can replicate in skin and in mucosal epithelial cells. Persistent infections of the HR-HPV genotypes are considered as the causative agents in more than 99% of cervical cancer cases. In our retrospective study, we aimed to determine the frequency of HPV and the presence of HPV16, HPV18 and other 12 HR-HPV genotypes in patients over the age of 18, from our region who applied to our university hospital.

Methods: Cervical brush sample in PreservCyt® solution and pap smear results of 685 patients over the age of 18 who applied to the gynecology and obstetrics outpatient clinic between September 2017 and April 2021, were included in our study. HPV genotyping was performed using the Roche Cobas® 4800 (Roche, Switzerland) fully automatic system in accordance with the manufacturer’s instructions.

Results: HPV was identified in 126 (18.4%) of 685 female patients included in our study. While HPV16 was detected in 4.5% of HR-HPV positive women, HPV18 was found in 1.8% and 12 other HR-HPV genotypes was found in 12.1%. While LSIL was detected in three, HSIL in two, and ASC-US in one of HPV16 positive patients, ASC-US was detected in only one of 12 HPV18 positive patients. One LSIL, one HSIL and four ASC-US were determined in patients with other high-risk HPV genotypes. As a result, the data obtained from our study showed that HR-HPV positivity in women admitted to our hospital in our region was compatible with some data in the world and in our country; however, it was relatively lower in general. Considering the genotype distribution, it led us to think that there were other HR-HPV genotypes besides HPV16 and HPV18 positivity.

Conclusion: The data obtained from our study showed that HR-HPV positivity in women from our region admitted to our hospital was relatively compatible with some of the data in both our country and the world; however, it was relatively lower in general. Considering the genotype distribution, we think that there are other HR-HPV genotypes other than HPV16 and HPV18 positivity, and although protection against HPV16 and HPV18 can be provided by vaccination, some HRHPV genotypes may be a problem in the future.