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2007, Cilt 37, Sayı 2, Sayfa(lar) 085-088
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Susceptibilities of Staphylococcus strains isolated from various clinical specimens to telithromycin
Selçuk Kaya, Emel Sesli Çetin, Buket Cicioğlu Arıdoğan, Tülay Tetik, Hayati Güneş, Mustafa Demirci
Süleyman Demirel Üniversitesi Tıp Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Isparta
Keywords: Antibiotic susceptibility, Staphylococcus, telithromycin

Telithromycin is a new ketolide antimicrobial, specifically developed for the treatment of community-acquired respiratory tract infections. In this study, we aimed to report the susceptibility rates of staphylococci isolated from various clinical specimens to telithromycin. Hundred and thirty-nine Staphylococcus strains [61 S.aureus and 78 coagulase negative staphylococci (CNS)] isolated from various clinical specimens were included in the study. Nineteen of S. aureus and 29 of CNS were methicillin resistant. Telithromycin resistance was tested by Kirby-Bauer disk diffusion method. Telithromycin resistance were detected in 32 of 139 (23 %) staphylococci strains, 8 (13) of which were S.aureus and 24 (31 %) were CNS. When considered for meticillin resistance, 4 of 19 MRSA (21 %) and 12 of 29 (41 %) CNS strains were found to be telithromycin resistant. Telithromycin resistance was found to be higher in CNS than in S.aureus (p<0.05) and higher in meticillin resistant strains than in susceptible ones althought the difference was insignificant (p>0.05) Activity of telithromycin was detected to be similar to that of clindamycin (p>0.05) and better than erithromycin (p=0.000). In conclusion, it would be convenient to use this antibiotic, produced for the treatment of community-acquired respiratory tract infections, according to the antibiogram results.

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