Caves as an part of folkloric properties such as health, shelter, rituel behaviours and stockbreeding are highly touristic area at the present day. Denizli region has recently opened touristic caves. Caves include different fungal organism due to climatic and geological variations. In this study, the presence of kerotinophilic fungi, Cryptococcus neoformans and Histoplasma capsulatum in Denizli Keloğlan cave have been investigated. 17 cave soil samples have been screened by standard methods. While keratinophilic fungi (4 Chrysosporium spp, 2 Chrysosporium keratinophilum), one nonsporulated fungi and one Microsporum canis have been isolated, C.neoformans and H.capsulatum have not been cultured. For our recently opened touristic caves, screening of their fungal pathogens is important for preventive medicine.