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2009, Cilt 39, Sayı 1-2, Sayfa(lar) 036-039
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ANTIBIOTIC SUSCEPTIBILITY AND FREQUENCY OF EXTENDED SPECTRUM BETA-LACTAMASE OF KLEBSIELLA PNEUMONIAE STRAINS ISOLATED FROM URINARY TRACT INFECTIONS
Banu KAŞKATEPE, Sulhiye YILDIZ
Ankara Üniversitesi Eczacılık Fakültesi Farmasötik Mikrobiyoloji Anabilim Dalı, Ankara
Keywords: Antibiotic resistance, ESBL, Klebsiella pneumoniae, urinary tract infection

Urinary tract infections are the most frequently encountered bacterial infections in outpatient clinics as well as nosocomial infections. Vast majority of the microorganisms that cause urinary tract infections are gram negative bacteria and Klebsiella pneumoniae is the second common pathogen. Th e aim of this study was to determine antibiotic susceptibility and extended spectrum beta lactamase (ESBL) production of the K.pneumoniae strains those were isolated in the Clinical Microbiology Laboratory, from urine samples of patients who presented to Ankara Dışkapı Yıldırım Beyazıt Training Hospital with urinary tract infections, in a period between October 2006 and March 2007. Conventional bacteriologic methods were used in identification and a total of 88 K.pneumoniae species were isolated. Sensitivity tests were performed according to the guidelines and criteria of NCCLS using Kirby-Bauer disk diff usion method. K.pneumoniae was most sensitive to amikacin (89%). Highest resistances were against ampicillin-sulbactam (54%) and trimethoprim-sulphametoxazole (42%). An increase in the rate of resistance to ciprofl oxacine (37%) was noted as well. Out of the isolated 88 strains, 22 (25%) were resistant to cefotaxime, 23(26%) to ceft riaxone, and 30 (34%) to cefuroxime. Extended spectrum beta lactamase (ESBL) production was investigated by double disk synergy method and 18 (20%) of the isolated K.pneumoniae strains were found to be ESBL producers.

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