2010, Cilt 40, Sayı 1, Sayfa(lar) 027-036 |
[ Türkçe Özet ]
[ PDF ]
[ Benzer Makaleler ]
|
The Role of Procalcitonin, C-Reactive Protein, Interleukin-6 Interleukin-8 and Endotoxin in the Early Diagnosis and Follow-up of the Sepsis |
Şua Sümer1, İbrahim Erayman2, Emel Türk Arıbaş2 |
1Düziçi Devlet Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji, Osmaniye 2Selçuk Üniversitesi Meram Tıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Konya |
Keywords: Sepsis, procalcitonin, C-reactive protein |
Objective: The gold standartd for the diagnosis of sepsis is a positive blood culture result in association with
specific clinical symptoms. However, since blood culture results are usually obtained too late, several markers of
infection are investigated for early diagnosis of sepsis. In this study procalcitonin, C-reactive protein, interleukin-
6, interleukin-8 and endotoxin values were evaluated as early diagnostic parameters of sepsis.
Materials and Methods: The study included 36 sepsis patients admitted to various departments and intensive care
units of Selçuk University Meram Medical School Hospital, Konya, Turkey between May 2006 and June 2007
and a control group of 20 healthy individuals.
Results: The cut-off values of the test parameters for the diagnosis of sepsis were found as 4.97 ng/ml for procalcitonin
92.7 mg/dl for C-reactive protein, 67.8 pg/ml for interleukin-6, 2.65 pg/ml for interleukin-8 and 1.85
pg/ml for endotoxin. The variation in leukocyte count, erythrocyte sedimentation rate, procalcitonin, C-reactive
protein, interleukin-6, interleukin-8 and endotoxin values measured on the 0 and 7th days of sepsis were found
statisticaly significant.
Conclusion: The most reliable marker for the diagnosis of sepsis was found to be procalcitonin. Although specificity
and sensitivity of C.reaktive protein and interleukin-6 were lower than procalcitonin, these parameters could
also help the clinician in the diagnosis of sepsis.
|
[ Türkçe Özet ]
[ PDF ]
[ Benzer Makaleler ]
|