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2014, Cilt 44, Sayı 4, Sayfa(lar) 139-143
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Metallo-Beta-Lactamases in Nosocomial Pseudomonas aeruginosa Isolates
Görkem YAMAN1, Aytekin ÇIKMAN2, Mehmet PARLAK3, Hüseyin GÜDÜCÜOĞLU3, Mustafa BERKTAŞ4
1Düzen Laboratuvarları, Mikrobiyoloji ve Tüberküloz Birimi, Ankara
2Mengücek Gazi Eğitim ve Araştırma Hastanesi, Tıbbi Mikrobiyoloji Kliniği, Erzincan
3Yüzüncü Yıl Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Van
4Özel Lokman Hekim Van Hastanesi, Mikrobiyoloji Laboratuvarı, Van
4Özel Lokman Hekim Van Hastanesi, Mikrobiyoloji Laboratuvarı
Keywords: Nosocomial infection, Pseudomonas aeruginosa, metallo-beta-lactamase

Objective: The aim of this study was to investigate the frequency of metallo-beta-lactamases (MBL) and antibiotic susceptibility profiles of nosocomial P. aeruginosa strains.

Material and Methods: A total of 62 imipenem resistant P. aeruginosa isolates identified as hospital-acquired according to the CDC criteria, were included in the study. The combined disc test was performed to determine the presence of MBL. Phoenix automated antibiotic susceptibility testing system (Becton Dickinson, USA) was used for the antibiotic susceptibility testing of imipenem-resistant P. aeruginosa isolates included in the study.

Results: The presence of MBL was detected by combined disc test in 53 (85%) of the imipenem resistant nosocomial P. aeruginosa isolates. The rates of resistance to the other tested antibiotics among the imipenem resistant isolates were found to be: amikacin 10%, ciprofloxacin 53%, ceftazidime 65%, levofloxacin 68%, aztreonam 84%, gentamicin 90%, piperacillin-tazobactam 92%, cefepime 97% and piperacillin 100%.

Conclusion: MBL production gradually increases among the nosocomial P. aeruginosa isolates. This enzyme which is responsible for resistance to beta-lactam agents, including the carbapenems, should routinely be tested in every laboratory by appropriate phenotypical methods and results should be reported. This practice will be of great value in preventing the spread of resistant isolates and for treatment success.


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