Cryptococcosis is an infection which gains importance with the rise of HIV/AIDS pandemic worldwide and its most common cause is Cryptococcus neoformans. History of contact with pigeons has an important place in the epidemiology of C. neoformans that can be seen anywhere in the world. This report presents an HIV negative, 75-yearold, female, with cirrhosis due to chronic HBV who applied to our hospital with complaints of headache, dizziness, abdominal pain, nausea and diplopia, and papular lesions on her face. Budding and encapsulated yeast cells were observed in Gram and negative stainings of the cerebrospinal fluid samples that were collected on admission from the patient who was inspected to have bilateral papilledema. Mucoid colonies of cream color in Sabouraud dextrose agar and brown color in birdseed (niger seed, Guizotia abyssinica) agar were grown on the third day of the culture. Budding and encapsulated yeast cells were detected in Gram smears of blood culture bottles that were positive 72 hours after admission to the hospital, and similar colonies were grown. Both of the two isolates were identified as C. neoformans by conventional methods and Vitek 2 (bioMérieux, France) system and as C. neoformans var. grubii by DNA sequencing analysis. Minimum inhibitory concentration values which were performed according to the “Clinical and Laboratory Standards Institute” M27-A3 document were determined for amphotericin-B (0.5 μg/ ml), fluconazole (0.125 μg/ml), itraconazole (0.5 μg/ml), posaconazole (0.25 μg/ml), voriconazole (<0.015 μg/ml), anidilofungin (16 μg/ml) and caspofungin (16 μg/ml). Papular lesions regressed after amphotericin-B and flucytosine treatment. Dialysis was implemented due to increasing creatinine values, however patient was lost due to emerging complications. Breeding pigeons in her balcony have been identified as the most important risk factor for the patient. Systemic spreading of yeast may have occurred due to prolonged inhalation of airborne pigeon excretions.