Listeria monocytogenes is usually a zoonotic infectious agent. It is an important pathogen that may cause infection in the elderly or in immunocompromised patients with predisposing conditions. The present case is presented to underline the necessity of keeping in mind that L. monocytogenes can be the cause of bacteremia in geriatric and immunocompromised patients. An 89-yearold patient, who was diagnosed as iron deficiency anemia four months before hospitalization, was hospitalized in the Internal Medicine Clinic and his blood samples were transferred to our laboratory for blood culture. Growth of catalase-positive, oxidase-negative gram-positive bacteria in the morphology of coccobacillus was observed in the blood culture. The isolated strain was identified as L. monocytogenes using the conventional methods and the automated system (VITEK 2, bioMérieux, France). The strain identified as L. monocytogenes by device was transferred to the Marmara University Pendik Training and Research Hospital Microbiology Laboratory and the bacterial identification was confirmed at the species level using Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) (Bruker Daltonics, Bremen, Germany) with mass spectrometer method in this center. In the susceptibility testing performed by disk diffusion method, it was established that the strain was found susceptible to most of the antibiotics and moderately susceptible to ciprofloxacin and levofloxacin. In conclusion, although L. monocytogenes is known as a rare cause of infection, it should be considered that factors such as age, malignancy or underlying chronic disease may enhance the tendency for listeriosis-like infections, as was observed in the present case. It would be reasonable to underline the necessity of keeping L. monocytogenes in mind in any meningitis case manifesting blood and cerebrospinal (CSF) signs and of planning the empirical therapy accordingly.