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2003, Cilt 33, Sayı 3, Sayfa(lar) 200-204
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Interaction Between Nitric Oxide and Respiratory Burst Responses of Mouse Peritoneal Macrophages against Salmonella typhimurium
Huseyin Baskın1, Nedim Çakır2, Nuran Yuluğ1
1 Dokuz Eylul University, School of Medicine, Department of Microbiology and Clinical Microbiology, İzmir
2 Dokuz Eylul University, School of Medicine, Department of Infectious Diseases and Clinical Microbiology, İzmir
Keywords: Nitric oxide, respiratory burst, macrophage, Salmonella typhimurium
Abstract
Nitric oxide (NO) and respiratory burst (RB) responses are major elements of the “oxygen dependent” defence mechanisms of macrophages, and since their roles have been also explained in human, many studies focused on NO and RB. In this study, NO and RB responses of mouse macrophages against live and dead forms of Salmonella typhimurium as an intracellular pathogen, and a possible relationship between these responses were evaluated. In live bacteria groups NO and RB responses were significantly higher while in dead bacteria groups responses were low. Inhibition of the NO response by an inhibitor (Nnitro-L-arginine methyl ester (L-NAME)), was not affected the RB responses. L-arginine addition was not effective on NO production if the response was not triggered. In conclusion, this study suggests that NO and RB relations, and effects of inhibitors and stimulators of them deserve further studies in order to explain their possible therapeutic effects on human diseases caused by intracellular pathogens.
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